Retrospective analysis on incidence and risk factors of early onset acute kidney injury after lung transplantation and its association with mortality

Renal Failure

Xiao-Xing Wang¹  Dan Zhang¹  Peng-Mei Li¹  Wen-Qian Chen¹  Wen-Wen Du¹  Xiang-Lin Zhang¹ 

[1] Department of Pharmacy, China-Japan Friendship Hospital;

关键词: acute kidney injury;    lung transplantation;    tacrolimus;    kdigo;    mortality;   

DOI  :  10.1080/0886022X.2021.1883652

来源: DOAJ

【 摘 要 】

Objectives Acute kidney injury (AKI) is a common complication after lung transplantation (LTx) which is closely related to the poor prognosis of patients. We aimed to explore potential risk factors and outcomes associated with early post-operative AKI after LTx. Methods A retrospective study was conducted in 136 patients who underwent LTx at our institution from 2017 to 2019. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guideline. Univariate and multivariate analyses were conducted to identify risk factors related to AKI. The primary outcome was the incidence of AKI after LTx. Secondary outcomes were associations between AKI and short-term clinical outcomes and mortality. Results Of the 136 patients analyzed, 110 developed AKI (80.9%). AKI was associated with higher baseline eGFR (odds ratio (OR) 1.01 (95% confidence interval (CI): 1.00–1.03)) and median tacrolimus (TAC) concentration (OR 1.15 (95% CI: 1.02–1.30)). Patients with AKI suffered longer mechanical ventilation days (p = .015) and ICU stay days (p = .011). AKI stage 2–3 patients had higher risk of 1-year mortality (HR 16.98 (95% CI: 2.25–128.45)) compared with no-AKI and stage 1 patients. Conclusions Our results suggested early post-operative AKI may be associated with higher baseline eGFR and TAC concentrations. AKI stage 1 may have no influence on survival rate, whereas AKI stage 2–3 may be associated with increased mortality at 1-year.

【 授权许可】

Unknown