Nutrition & Metabolism | |
Dietary resistant starch dose-dependently reduces adiposity in obesity-prone and obesity-resistant male rats | |
关键词: Resistant starch; Adiposity; Incretin; Short chain fatty acid; Insulin sensitivity; | |
DOI : 10.1186/1743-7075-9-93 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
Animal studies show that diets containing resistant starch (RS) at levels not achievable in the human diet result in lower body weight and/or adiposity in rodents. We aimed to determine whether RS dose-dependently reduces adiposity in obesity-prone (OP) and obesity-resistant (OR) rats.
Methods
Male Sprague–Dawley rats (
Results
Obesity prone rats gained less weight with 4, 12 and 16% RS compared to 0% RS, but the effect in OR animals was significant only at 16% RS. Irrespective of phenotype, diets containing ≥8% RS reduced adiposity compared to 0% RS. Energy intake decreased by 9.8 kJ/d for every 4% increase in RS. All diets containing RS increased total SCFA pools in the caecum and lowered plasma GIP concentrations compared to the 0% RS, whereas plasma GLP-1 and PYY were increased when the diet contained at least 8% RS. Insulin sensitivity was not affected by RS.
Conclusion
RS in amounts that could be potentially consumed by humans were effective in reducing adiposity and weight gain in OP and OR rats, due in part to a reduction in energy intake, and changes in gut hormones and large bowel carbohydrate fermentation.
【 授权许可】
Unknown