Potential of Chemical and Physical Enhancers for Transungual Delivery of Amorolfine Hydrochloride

Materials

Vitalis Briedis¹  Indrė Šveikauskaitė¹  Alius Pockevičius² 

[1] Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, 50161 Kaunas, Lithuania;Department of Veterinary Pathobiology, Lithuanian University of Health Sciences, Tilžės g. 18, 50161 Kaunas, Lithuania;

关键词: transungual delivery;    polymeric nail lacquers;    amorolfine hydrochloride;    chemical enhancement;    fractional laser;    onychomycosis;   

DOI  :  10.3390/ma12071028

来源: DOAJ

【 摘 要 】

Topical monotherapy of nail infection is limited by poor drug permeability into the human nail plate. Numerous substances and methods are applied to improve the antifungal agent delivery across the nail plate. This work aimed to evaluate the effect of chemical and physical enhancers on the accumulation and permeation of amorolfine hydrochloride through human nail clippings. Polymeric nail lacquers with Eudragit E100 were developed as a potentially suitable delivery system for amorolfine hydrochloride. Incorporating thioglycolic acid and urea into formulations provided increased accumulation of antifungal agent in nail layers of up to 100% and 57%, respectively. Structural changes of nail barrier, induced by fractional CO₂ laser, were visualized by microscopy. The permeation of amorolfine hydrochloride through the nail increased twofold when thioglycolic acid-containing formulation was applied and the nail was pretreated with a fractional CO₂ laser. The results suggest that this novel combination of enhancers has the potential to be an effective option for topical drug delivery through the nail, and increased the efficacy of treatment.

【 授权许可】

Unknown