Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

Pharmaceuticals

Elisabetta Orlandini¹  Susanna Nencetti²  Lidia Ciccone²  Jennifer Vandooren³ 

[1] Department of Earth Sciences, University of Pisa, via Santa Maria 53, 56126 Pisa, Italy;Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy;Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, KU Leuven—Herestraat 49—Box 1044, 3000 Leuven, Belgium;

关键词: MMP-2;    MMP-9;    Alzheimer’s disease;    AD;    neurodegeneration;    neuroinflammation;   

DOI  :  10.3390/ph14020086

来源: DOAJ

【 摘 要 】

Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer’s disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on natural marine and terrestrial compounds, as well as their ability to modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer’s disease.

【 授权许可】

Unknown