The Usefulness of Serum Biomarkers in the Early Stages of Diabetic Retinopathy: Results of the EUROCONDOR Clinical Trial

Journal of Clinical Medicine

José Cunha-Vaz¹  Luísa Ribeiro¹  Berta Ponsati²  SimonP. Harding³  Massimo Porta⁴  Pascale Massin⁵  Rosangela Lattanzio⁶  Francesco Bandello⁶  Edoardo Midena⁷  GabrieleE. Lang⁸  José García-Arumí⁹  Jonathan Gibson^1,10  Cristina Hernández^1,11  Rafael Simó^1,11  StephenJ. Aldington^1,12  Peter Scanlon^1,12  Catherine Egan^1,13  Ulrik Frydkjaer-Olsen^1,14  Jakob Grauslund^1,14 

[1] Association for Innovation and Biomedical Research on Light and Image (AIBILI), 3000-548 Coimbra, Portugal;BCN Peptides, 08777 Barcelona, Spain;Department of Eye & Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, and St. Pauls’ Eye Unit. Liverpool University Hospitals, members of Liverpool Health Partners, Liverpool L69 7ZX, UK;Department of Medical Sciences, University of Turin, 10124 Turin, Italy;Department of Ophthalmology, Lariboisière Hospital, 75004 Paris, France;Department of Ophthalmology, Scientific Institute San Raffaele, University Vita-Salute, 20132 Milano, Italy;Department of Ophthalmology, University of Padova, 35122 Padova, Italy;Department of Ophthalmology, University of Ulm, 89081 Ulm, Germany;Department of Ophthalmology, Vall d’Hebron University Hospital, 08035 Barcelona, Spain;Department of Vision Sciences, Aston University, Birmingham B4 7ET, UK;Diabetes and Metabolism Research Unit and CIBERDEM, Vall d’Hebron Research Institute, 08035 Barcelona, Spain;Gloucestershire Hospitals National Health Service Foundation Trust, Cheltenham GL53 7AG, UK;Moorfields Eye Hospital National Health Service Foundation Trust, Institute of Ophthalmology/University College London, London EC1V 2PD, UK;Research Unit of Ophthalmology, Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark;

关键词: diabetic retinopathy;    retinal neurodegeneration;    serum biomarkers;    laminin;    carboxy methyl lysine;    asymmetric dimethylarginine;   

DOI  :  10.3390/jcm9041233

来源: DOAJ

【 摘 要 】

The main aim of this study was to evaluate the ability of serum biomarkers to predict the worsening of retinal neurodysfunction in subjects with type 2 diabetes. For this purpose, we measured selected molecules (N-epsilon-carboxy methyl lysine (CML), laminin P1 (Lam-P1), and asymmetric dimethylarginine (ADMA)) in the serum of 341 participants of the EUROCONDOR study at baseline, 24, and 48 weeks. Retinal neurodysfunction was assessed by measuring implicit time (IT) using multifocal electroretinography, and structural changes were examined by spectral domain–optical coherence tomography. The values of IT at baseline were directly correlated with baseline serum concentrations of CML (r = 0.135, p = 0.013). Furthermore, in the placebo group, increase in CML concentration throughout follow-up correlated with the IT (r = 0.20; p = 0.03). Baseline serum levels of CML also correlated with macular retinal thickness (RT) (r = 0.231; p < 0.001). Baseline Lam-P1 levels correlated with the increase of the RT at the end of follow-up in the placebo group (r = 0.22; p = 0.016). We provide evidence that CML may be a biomarker of both retinal neurodysfunction and RT, whereas Lam-P1 was associated with RT only. Therefore, circulating levels of these molecules could provide a complementary tool for monitoring the early changes of diabetic retinopathy (DR).

【 授权许可】

Unknown