Solvent-Induced Supramolecular Assembly of a Peptide-Tetrathiophene-Peptide Conjugate

Frontiers in Chemistry

Zongxia Guo¹  Xiao Zhang²  Yujiao Wang²  Youbing Mu³  Xiaobo Wan³  Ruiying Gong⁴ 

[1] College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, China;Key Laboratory of Biobased Polymer Materials, Shandong Provincial Education Department, College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, China;Key Laboratory of Optoelectronic Chemical Materials and Devices, School of Chemical and Environmental Engineering, Jianghan University, Ministry of Education, Wuhan, China;Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China;

关键词: oligopeptide;    oligothiophene;    peptide-tetrathiophene-peptide;    supramolecular assembly;    supramolecular chirality;   

DOI  :  10.3389/fchem.2019.00467

来源: DOAJ

【 摘 要 】

The assembly of a peptide-tetrathiophene-peptide (PTP) conjugate has been investigated in mixed solvents, which has different polarities by changing the solvent proportions. It was found that PTP can form fibers in THF/hexane solutions with 40–80%v of hexane. The fibers were stable and did not change on time. On the other hand, PTP formed ordered structures in a mixed solution with the water content from 40 to 60%v. For the as-prepared solutions, two nanostructures vesicles and parallelogram sheets were obtained. The parallelogram sheets could transform into vesicles on time. The fibers showed supramolecular chirality, however, there was no Cotton effect for vesicles and parallelogram sheets. UV-vis, FL, XRD, FT-IR, and CD spectra together with SEM, AFM, TEM were used to characterize the nanostructures and properties of the assemblies. Molecular packing mechanism was proposed based on the experimental data.

【 授权许可】

Unknown