Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials

Gels

Ali Zarrabi¹  Zeliha Yetim²  Ferdows Afghah³  Bahattin Koc³  Efsun Senturk³  Ali Fallah³  Saltuk B. Hanay³  Rajender S. Varma⁴  Hulya Yilmaz⁵  Mustafa Culha⁵ 

[1] Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Turkey;Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey;Faculty of Engineering and Natural Sciences (FENS), Sabanci University, Istanbul 34956, Turkey;Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, 78371 Olomouc, Czech Republic;Sabancı University Nanotechnology Research and Application Center—SUNUM, Istanbul 34956, Turkey;

关键词: hydrogels;    urazole;    ion-exchange;    porous gels;    biomaterials;   

DOI  :  10.3390/gels7040261

来源: DOAJ

【 摘 要 】

In this study, the acidity of urazole (pKa 5–6) was exploited to fabricate a hydrogel in two simple and scalable steps. Commercially available poly(hexamethylene)diisocyanate was used as a precursor to synthesize an urazole containing gel. The formation of urazole was confirmed by FT-IR and ¹H-NMR spectroscopy. The hydrogel was characterized by microscopy imaging as well as spectroscopic and thermo-gravimetric analyses. Mechanical analysis and cell viability tests were performed for its initial biocompatibility evaluation. The prepared hydrogel is a highly porous hydrogel with a Young’s modulus of 0.91 MPa, has a swelling ratio of 87%, and is capable of exchanging ions in a medium. Finally, a general strategy was demonstrated to embed urazole groups directly into a crosslinked material.

【 授权许可】

Unknown