Classical and microwave assisted synthesis of new 4-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylazo)-N-(2-substituted-4-oxo-4H-quinazolin-3-yl)benzenesulfonamide derivatives and their antimicrobial activities

Journal of Saudi Chemical Society

Ritu B. Dixit¹  Jayanti P. Patel²  Natvar A. Sojitra²  Bharat C. Dixit²  Rajesh K. Patel³ 

[1] Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyangar 388 121, Gujarat, India;Chemistry Department, V.P. & R.P.T.P. Science College, Affiliated to Sardar Patel University, Vallabh Vidyangar 388 120, Gujarat, India;Department of Life Sciences, Hemchandracharya North Gujarat University, Patan 384 265, Gujarat, India;

关键词: Quinazolinone;    Hydrazono;    Pyrazole;    Microwave;    Antimicrobial;   

DOI  :  10.1016/j.jscs.2012.07.020

来源: DOAJ

【 摘 要 】

A simple and efficient methodology was developed for the synthesis of new 4-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylazo)-N-(2-substituted-4-oxo-4H-quinazolin-3-yl)benzenesulfonamide derivatives 10a–10j in good amount of yields. They have been prepared using 2-acetamidobenzoic acid derivatives 2a–2j via intermediates benzenesulfonamide substituted quinazolinone derivatives 8a–8j, and its corresponding hydrazono derivatives 9a–9j. Entitled compounds (10a–10j) were also obtained using microwave heating in good amount of yields. The structures of all the new compounds have been evaluated on the basis of elemental analysis, FT-IR, 1H and 13C NMR spectral studies. Entitle compounds have been screened for their in vitro antimicrobial activities and all these compounds displayed excellent to moderate activities, which were found to be significantly potent against bacteria compared to fungal.

【 授权许可】

Unknown