Prevalence of Pruritus and Association with Anxiety and Depression in Patients with Nonalcoholic Fatty Liver Disease

Biomedicines

David Petroff¹  Thomas Karlas²  Johannes Wiegand³  Florian van Boemmel³  Florian Gerhardt³  Albrecht Boehlig³  Thomas Berg³  Valentin Blank⁴ 

[1] Clinical Trial Center Leipzig, University of Leipzig, Härtelstraße 16/18, 04107 Leipzig, Germany;Division of Gastroenterology, Department of Medicine II, Leipzig University Medical Center, Liebigstraße 20, 04103 Leipzig, Germany;Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Liebigstraße 20, 04103 Leipzig, Germany;Integrated Research and Treatment Center Adiposity Diseases Leipzig, Faculty of Medicine, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany;

关键词: non-alcoholic steatohepatitis (NASH);    pruritus;    anxiety;    depression;    vibration controlled transient elastography (VCTE);    FXR agonist;   

DOI  :  10.3390/biomedicines10020451

来源: DOAJ

【 摘 要 】

Patient-reported outcomes are important in nonalcoholic fatty liver disease (NAFLD). Pruritus is of special interest for evolving therapies with farnesoid X receptor (FXR) agonists. The aim of this study was to investigate the prevalence of pruritus in a real-life NAFLD cohort and analyze associations with anxiety and depression. Pruritus was assessed using a visual analogue- (VAS) and 5-D itch-scale (5-D). Anxiety and depression were evaluated by Beck’s-Depression-Inventory (BDI) and the Hospital Anxiety and Depression Scale (HADS-A, HADS-D). An optimal logistic regression model was found with a stepwise procedure to investigate variables associated with pruritus. In total, 123 NAFLD patients were recruited. VAS and 5-D were highly correlated (Spearman’s correlation coefficient 0.89). Moderate/severe pruritus was reported in 19% (VAS) and 21% (5-D) of patients. Anxiety and depression were present in 12% and 4% (HADS-A and HADS-D, respectively) and 12% (BDI) of cases. There was a significant association between VAS and BDI (p = 0.019). The final multivariate model for 5-D included diabetes mellitus (OR 4.51; p = 0.01), BDI (OR 5.98; p = 0.024), and HADS-A (OR 7.75; p = 0.011). One-fifth of NAFLD patients reported moderate or severe pruritus. 5-D was significantly associated with diabetes mellitus, depression, and anxiety. These findings should be tested in larger populations and considered in candidates for treatment with FXR agonists.

【 授权许可】

Unknown