Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia

Frontiers in Aging Neuroscience

S Gydesen¹  J Brown¹  E Englund¹  I Holm¹  T Thusgaard¹  The FReJA Consortium¹  TT Nielsen¹  A Gade¹  E Fisher¹  AM Isaacs¹  J Collinge¹  Jette Stokholm Pedersen²  Peter Johannsen²  Peter Roos²  Christian Sandøe Musaeus²  Troels Wesenberg Kjær³  Jørgen Erik Nielsen³  Gunhild Waldemar³  Theis Bacher⁴  Maria Joy Normann Haverberg⁴ 

[1] ;Danish Dementia Research Centre (DDRC), Rigshospitalet and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark;Department of Neurology, Zealand University Hospital, Roskilde, Denmark;

关键词: EEG;    microstates;    spectral power;    FTD;    Frontotemporal dementia;    CHMP2B;   

DOI  :  10.3389/fnagi.2021.714220

来源: DOAJ

【 摘 要 】

A rare cause of inherited frontotemporal dementia (FTD) is a mutation in the CHMP2B gene on chromosome 3 leading to the autosomal dominantly inherited FTD (CHMP2B-FTD). Since CHMP2B-FTD is clinically well-characterized, and patients show a distinct pattern of executive dysfunction, the condition offers possible insight in the early electroencephalographic (EEG) changes in the cortical networks. Specifically, EEG microstate analysis parses the EEG signals into topographies believed to represent discrete network activations. We investigated the EEG dynamics in patients with symptomatic CHMP2B-FTD (n = 5) as well as pre-symptomatic mutation carriers (n = 5) compared to non-carrier family members (n = 6). The data was parsed into four archetypal microstates and global power was calculated. A trend was found for lower occurrence in microstate D in CHMP2B-FTD (p-value = 0.177, F-value = 2.036). Patients with recent symptom onset (<1 year) showed an increased duration of microstate D, whereas patients who had been symptomatic for longer periods (>2 years) showed decreased duration. Patients with CHMP2B-FTD present with executive dysfunction, and microstate D has previously been shown to be associated with the fronto-parietal network. The biphasic pattern may represent the pathophysiological changes in brain dynamics during neurodegeneration, which may apply to other neurodegenerative diseases.

【 授权许可】

Unknown