Correlation Between Optical Coherence Tomography and Photopic Negative Response of Flash Electroretinography in Ganglion Cell Complex Assessment in Glaucoma Patients

Clinical Ophthalmology

关键词: glaucoma;    retinal ganglion cells;    standard automated perimetry;    optical coherence tomography;    photopic negative response;    electroretinography;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mohammad Hasan Awwad, Ossama Nada, Momen Mahmoud Hamdi, Amany Abd El-Fattah El-Shazly, Sheriff Elwan Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Mohammad Hasan Awwad, Misr Lel Tayaran St., New Nozha, Cairo, 11843, Egypt, Tel [phone], Email [e-mail]: To investigate the correlation between the photopic negative response (PhNR) of the light-adapted flash electroretinography (ERG) and measurements of standard automated perimetry (SAP) and optical coherence tomography (OCT) in assessment of retinal ganglion cells’ (RGCs) affection in glaucoma.Patients and Methods: A cross-sectional study included 40 eyes of glaucoma patients and 40 eyes of age- and gender-matched normal subjects. Participants underwent a complete ophthalmologic assessment, SAP, OCT, and light-adapted flash ERG using the extended PhNR protocol of the International Society for Clinical Electrophysiology of Vision (ISCEV). Glaucomatous eyes were divided into 3 subgroups: mild (n = 15), moderate (n = 11) and severe glaucoma (n = 14) according to the mean deviation (MD) of SAP. Measurements of SAP, OCT and ERG parameters were analyzed, and correlations between PhNR measurements and other study measurements were evaluated.Results: PhNR amplitudes and PhNR/b-wave ratios were significantly reduced in glaucoma cases compared to healthy controls, and they showed a significant and progressive decline across the three glaucoma subgroups (P < 0.05). An exception to this is PT (b-wave peak to PhNR trough) PhNR amplitude where its reduction was statistically non-significant when comparing between controls and mild glaucoma cases (P = 0.178), and between moderate and severe glaucoma cases (P = 0.714). PhNR amplitudes and PhNR/b-wave ratios correlated significantly with SAP and OCT parameters (P < 0.05).Conclusion: PhNR correlates well with SAP and OCT parameters in glaucoma assessment. PhNR could be a valuable supplementary tool for objective assessment of the RGCs’ function in glaucoma.Keywords: glaucoma, retinal ganglion cells, standard automated perimetry, optical coherence tomography, photopic negative response, electroretinography

【 授权许可】

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