An unusual presentation of chronic lymphocytic leukemia

Avicenna Journal of Medicine

Jeanette Ramos¹  Mihir Raval¹  Appalanaidu Sasapu¹  Dinesh Atwal¹  Belal Firwana¹ 

[1] Department of Hematology Oncology, University of Arkansas for Medical Sciences, Winthrop Rockefeller Cancer Institute, Little Rock, Arkansas, USA;

关键词: chronic lymphocytic leukemia;    hyperleukocytosis;    leukostasis;   

DOI  :  10.4103/ajm.AJM_171_16

来源: DOAJ

【 摘 要 】

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a B-cell lymphocytic neoplasm with indolent clinical course. If identified early, observation is opted. Many variables lead to the initiation of treatment. Authors describe a 62-year-old male presenting with shortness of breath and found to have white cell count of 1360 × 109/L and subsequently was diagnosed with CLL/SLL. The patient received leukapheresis along with tumor lysis treatment and systemic chemotherapy with fludarabine, cyclophosphamide, and rituximab regimen. His course was complicated with deep venous thrombosis, extensive cutaneous, and sinus mucosa involvement by CLL/SLL. The patient clinically improved and on follow-up clinic visits documented normalization of his white cell counts. The case report brings up a rare presentation of CLL/SLL with such an extreme high white cell count, leukostasis symptoms and extramedullary involvement of disease and encourages providers to be vigilant of rare presentation of CLL/SLL.

【 授权许可】

Unknown