Serum Vitamin D level in Jordanian patients with exfoliation syndrome and exfoliative glaucoma

Guoji Yanke Zazhi

Mustafa R Al-Hashimi¹  Alaa Al-Dabbagh²  Majd Al-Shalakhti³  Wisam A Shihadeh³  Saied A Jaradat³  Yousef Khader³  Mohammed B Khalil³ 

[1] Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan;Department of Ophthalmology, Islami Hospital, Amman 11190, Jordan;Faculty of Medicine, Jordan University of Science & Technology, Irbid 22110, Jordan;

关键词: Vitamin D;    exfoliation syndrome;    exfoliative glaucoma;    exfoliative glaucoma;   

DOI  :  10.3980/j.issn.1672-5123.2018.5.03

来源: DOAJ

【 摘 要 】

AIM: To compare the level of serum Vitamin D in patients with exfoliation syndrome(XFS)and exfoliative glaucoma(XFG)with that in control subjects.

METHODS: Serum levels of 25-hydroxy Vitamin D(Vitamin D)were measured using liquid chromatography. Variables like age, sex and medical history of hypertension, diabetes mellitus and ischemic heart disease were reported.

RESULTS: This study included a total of 55 patients with XFS/XFG and 60 control subjects. Patients with XFS/XFG were significantly older than control subjects(mean age: 71.8y vs 67.5y, P=0.002). Gender distribution was similar. The prevalence rates of diabetes, hypertension, and ischemic heart disease were not significantly different between the two groups. The mean of Vitamin D was 14.7 ng/mL for patients with XFS/XFG and 14.9 ng/mL for control subjects with no significant difference. Although Vitamin D level was lower in the XFS/XFG group but multivariate analysis did not show significant difference in Vitamin D deficiency between the two groups after adjusting for age, gender, and medical conditions.

CONCLUSION: The outcomes of our study are different from those in the literature. Vitamin D levels were low in both the XFS/XFG group and the control group being lower in the first one but that difference was not statistically significant. XFS and Vitamin D deficiency share common associations with certain systemic diseases. Further studies with larger numbers are needed to elaborate more on these associations and to support further the controversial literature.

【 授权许可】

Unknown