The dynamics of the morphological status of the gastric mucosa in the early post-eradication period in children

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Наталія Романівна Кеч¹  Олена Львівна Личковська¹  Ірина Юріївна Кулачковська¹  Олег-Роман Зиновійович Гнатейко¹  Вікторія Дмитрівна Семен²  Людмила Ярославівна Чекан² 

[1] Danylo Halytskyi Lviv National Medical University69 Pekarska str., Lviv, Ukraine, 79010;Lviv Regional Child’s Clinical Hospital “Ohmatdyt”31 Lysenko str., Lviv, Ukraine, 79008;

关键词: children;    gastroduodenal zone;    eradication therapy;    Helicobacter pylori;    Lactobacillus reuteri;   

DOI  :  10.15587/2313-8416.2016.64430

来源: DOAJ

【 摘 要 】

Helicobacter pylori (Нр) in 60–80 % of cases is the cause of forming the gastric ulcer and in у 90–95 % – the duodenum ulcer, there was also proved its connection with appearance of adenocarcinomas and gastric lymph. But elimination of Нр does not lead to the stopping of inflammatory response of mucosa. The search for the ways of control of the mucosa inflammatory response along with eradication of Нр-infection is a topical problem of children gastroenterology.

Aim of research was the study of influence of probiotic that contains Lactobacillus reuteri DSM 17938 on inflammatory changes of gastric mucosa in children with destructive forms of gastroduodenal zone pathology after successful eradication therapy.

Materials and methods of research. There were examined 98 children 8–13 years old with destructive forms of gastroduodenal pathology. The verification of diagnosis and treatment was carried out according to the actual Ukrainian MHP protocols of giving help to the children with gastroduodenal pathology. Diagnostics of Нр was carried out using histological method and detection of Нр antigen in excrements. At morphological study of mucosa bioptats there were assessed the degree of intensity of the chronic inflammatory process, its activity, presence and intensity of mucosa atrophy and metaplasia. The main group (MG) included 53 children who received the eradication therapy from the very beginning and during the month after its end received preparations that contain Lactobacillus reuteri; the control group (CG) included 45 children who received an analogous treatment but probiotics were prescribed if necessary and only at the time of taking antibiotics.

Results of research. The results of morphological studies in children from the MG demonstrated the considerably less intense inflammatory changes of mucosa than in children from the CG. Especially the degree of inflammatory process severity and activity were statistically reliably lower in MG comparing with CG. The part of patients with the symptoms of mucosa atrophy decreased more essentially in MG but the difference was not reliable.

Conclusions. After elimination of Нр in children the inflammatory changes of gastric mucosa that can be the cause of the further mucosa lesion remain stable. Prescription of probiotics that include Lactobacillus reuteri DSM 17938 resulted in decrease of inflammatory changes and it can be considered as the variant of effective and safe therapy of children in post-eradication period

【 授权许可】

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