A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya

BMC Research Notes

Charles R. Newton¹  Michael Mwaniki¹  Paul Mwangi¹  Shebe Mohammed¹  Raphael Kalu¹  Dorcas N. Magai¹  Amina Abubakar¹  Hans M. Koot²  Anne L. Gordon³ 

[1] Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Wellcome Trust Research Programme;Department of Clinical Neuro- and Developmental Psychology, Vrije Universiteit;Faculty of Life Sciences and Medicine, King’s College London;

关键词: Albumin;    Saline;    Neonates;    Neonatal jaundice;    Sub-Saharan Africa;   

DOI  :  10.1186/s13104-019-4632-2

来源: DOAJ

【 摘 要 】

Abstract Objective The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. Results One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3–6) days, and the median gestation was 36 (IQR 36–38) weeks. No significant differences were found in the change in TSB (Mann–Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann–Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754.

【 授权许可】

Unknown