Non-mammalian models in behavioral neuroscience: Consequences for biological psychiatry

Frontiers in Behavioral Neuroscience

Luana Ketlen Reis Leão¹  Anderson Manoel Herculano¹  Tayana Silva de Carvalho¹  Karen Renata Matos Oliveira¹  Monica Gomes Lima¹  Caio eMaximino²  Hellen eBarbosa³  Rhayra Xavier do Carmo Silva³  Suéllen de Nazaré dos Santos da Silva³  Laís do Socorro dos Santos Rodrigues³ 

[1] Universidade Federal do Pará;Universidade Federal do Sul e Sudeste do Pará;Universidade do Estado do Pará;Universität Duisburg-Essen;

关键词: Biological Psychiatry;    Invertebrates;    behavioral models;    teleost fish;    Anamniotes;    Sauropsida;   

DOI  :  10.3389/fnbeh.2015.00233

来源: DOAJ

【 摘 要 】

Current models in biological psychiatry focus on a handful of model species, and the majority of work relies on data generated in rodents. However, in the same sense that a comparative approach to neuroanatomy allows for the idenfication of patterns of brain organization, the inclusion of other species and an adoption of comparative viewpoints in behavioral neuroscience could also lead to increases in knowledge relevant to biological psychiatry. Specifically, this approach could help to identify conserved features of brain structure and behavior, as well as to understand how variation in gene expression or developmental trajectories relates to variation in brain and behavior pertinent to psychiatric disorders. To achieve this goal, the current focus on mammalian species must be expanded to include other species, including non-mammalian taxa. In this article, we review behavioral neuroscientific experiments in non-mammalian species, including traditional 'model organisms' (zebrafish, Drosophila and C. elegans) as well as in other species which can be used as 'reference'. The application of these domains in biological psychiatry and their translational relevance is considered.

【 授权许可】

Unknown