Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer

Journal of Clinical Medicine

Sonia Minuzzo¹  ElenaLaura Mazzoldi²  Ilaria Piga²  Anna Pastò²  Alberto Amadori²  Giorgia Pilotto²  Stefano Indraccolo²  Massimo Carella³  Pietro Palumbo³  MariaOrnella Nicoletto⁴  Simona Frezzini⁴ 

[1] Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy;Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, 35128 Padova, Italy;Medical Genetics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy;Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, 35128 Padova, Italy;

关键词: ovarian cancer;    cancer stem cell;    genetic heterogeneity;    snp array;   

DOI  :  10.3390/jcm9020368

来源: DOAJ

【 摘 要 】

The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.

【 授权许可】

Unknown