Engineering CAR-T cells

Biomarker Research

Cheng Zhang¹  Xi Zhang¹  Jun Liu¹  Jiang F. Zhong² 

[1] Department of Hematology, Xinqiao Hospital, Third Military Medical University;Division of Periodontology, Diagnostic Sciences & Dental Hygiene, and Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California;

关键词: Chimeric antigen receptor redirected T cells;    CAR-T cells;    Structure;    Evolution;    Production;    Viral vector;   

DOI  :  10.1186/s40364-017-0102-y

来源: DOAJ

【 摘 要 】

Abstract Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells.

【 授权许可】

Unknown