Infection related catheter complications in patients undergoing prone positioning for acute respiratory distress syndrome: an exposed/unexposed study

BMC Infectious Diseases

Christophe Goetz¹  Hélène Hochard²  Nejla Aissa³  Guillaume Louis⁴  Thibaut Belveyre⁴  Emmanuel Novy⁴  Bruno Levy⁵  Audrey Jacquot⁵  Antoine Kimmoun⁵ 

[1] Clinical Research Support Unit, Metz-Thionville Regional Hospital;Department of Bacteriology, Metz-Thionville Regional Hospital, Mercy Hospital;Department of Bacteriology, University Hospital of Nancy;Intensive Care Unit, Metz-Thionville Regional Hospital, Mercy Hospital;Medical intensive Care Unit, University Hospital of Nancy;

关键词: Colonization;    Catheter-related infection;    ARDS;    Prone positioning;   

DOI  :  10.1186/s12879-021-06197-2

来源: DOAJ

【 摘 要 】

Abstract Background Prone positioning (PP) is a standard of care for patients with moderate–severe acute respiratory distress syndrome (ARDS). While adverse events associated with PP are well-documented in the literature, research examining the effect of PP on the risk of infectious complications of intravascular catheters is lacking. Method All consecutive ARDS patients treated with PP were recruited retrospectively over a two-year period and formed the exposed group. Intensive care unit (ICU) patients during the same period without ARDS for whom PP was not conducted but who had an equivalent disease severity were matched 1:1 to the exposed group based on age, sex, centre, length of ICU stay and SAPS II (unexposed group). Infection-related catheter complications were defined by a composite criterion, including catheter tip colonization or intravascular catheter-related infection. Results A total of 101 exposed patients were included in the study. Most had direct ARDS (pneumonia). The median [Q1–Q3] PP session number was 2 [1–4]. These patients were matched with 101 unexposed patients. The mortality rates of the exposed and unexposed groups were 31 and 30%, respectively. The incidence of the composite criterion was 14.2/1000 in the exposed group compared with 8.2/1000 days in the control group (p = 0.09). Multivariate analysis identified PP as a factor related to catheter colonization or infection (p = 0.04). Conclusion Our data suggest that PP is associated with a higher risk of CVC infectious complications.

【 授权许可】

Unknown