Case Report: Nicolau syndrome due to etofenamate injection [version 1; referees: 2 approved]

F1000Research

Aysegul Baykan¹  Yılmaz Ulas²  Ragıp Ertas²  Kemal Ozyurt²  Atıl Avcı²  Emin Ozlu³  Halit Baykan⁴ 

[1] Department of Dermatology, Kayseri Tekden Hospital, Kayseri, 38000, Turkey;Department of Dermatology, Kayseri Training and Research Hospital, Kayseri, 38010, Turkey;Department of Dermatology, School of Medicine, Duzce University, Duzce, 81620, Turkey;Department of Plastic and Reconstructive Surgery, Kayseri Training and Research Hospital, Kayseri, 38010, Turkey;

关键词: Drug Eruptions;   

DOI  :  10.12688/f1000research.11705.1

来源: DOAJ

【 摘 要 】

Nicolau syndrome, also known as embolia cutis medicomentosa, is a rare complication characterized by tissue necrosis that occurs after injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery and cytotoxic effects of the drug. Severe pain in the immediate postinjection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease. Etofenamate is a non-steroidal anti-inflammatory drug and a non-selective cyclooxygenase inhibitor. Cutaneous adverse findings caused by etofenamate are uncommon. Herein, we present a case with diagnosis of Nicolau syndrome due to etofenamate injection, which is a rare occurrence.

【 授权许可】

Unknown