The roles of circular RNAs in human development and diseases

Biomedicine & Pharmacotherapy

Mayuren Candasamy¹  Subrat Kumar Bhattamisra²  Ramkumar Rajendran²  Elaine Wan Ling Chan³  Sze Wei Tan⁴  Ee Neng Leong⁴  Eric Chun Shen Lee⁴  Grace Pei Ling Lim⁴  Weng Hong Kok⁴  Sean Hong Tan⁴  Safa Abdelgadir Mohamed Elhassan⁵ 

[1] Corresponding authors.;Department of Life Sciences, School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia;Institute of Research, Development and Innovation, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia;School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia;School of Postgraduate Studies, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia;

关键词: Circular RNAs;    Organogenesis;    Development;    Biomarkers;    Diseases;    Systems;   

DOI  :  

来源: DOAJ

【 摘 要 】

For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed.

【 授权许可】

Unknown