Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Frontiers in Endocrinology

Anne-Laure Barbotin¹  Agathe Dumont²  Sophie Catteau-Jonard³  Didier Dewailly⁴  Geoffroy Robin⁵ 

[1] CHU Lille, Institut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Lille, France;CHU Lille, Service d'Assistance Médicale à la Procréation et Préservation de la Fertilité, Hôpital Jeanne de Flandre, Lille, France;CHU Lille, Unité Fonctionnelle de Gynécologie Endocrinienne, Service de Gynécologie Médicale, Orthogénie et Sexologie, Hôpital Jeanne de Flandre, Lille, France;Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, France;Lille University, EA 4308 “Gametogenesis and Gamete Quality”, Lille, France;

关键词: anti-müllerian hormone;    polycystic ovary syndrome;    androgens;    follicle;    FSH;    anovulation;   

DOI  :  10.3389/fendo.2020.00641

来源: DOAJ

【 摘 要 】

Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.

【 授权许可】

Unknown