Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy

Molecules

Teng-Teng Liu¹  Xiao-Wei Nie¹  Meng-Yuan Zhu¹  Hai-Jian Sun¹  Lei Cao¹  Lei Guo¹  Zhi-Yuan Wu¹  Jin-Song Bian¹  Ye Lin² 

[1] Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore;School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China;

关键词: hydrogen sulfide;    renal physiology;    oxidative stress;    renin-angiotensin system;    diabetic nephropathy;   

DOI  :  10.3390/molecules24152857

来源: DOAJ

【 摘 要 】

Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major cause of chronic kidney diseases (CKD) and end stage kidney disease (ESKD) worldwide. Hydrogen sulfide (H₂S), the third gasotransmitter after nitric oxide (NO) and carbon monoxide (CO), is synthesized in nearly all organs, including the kidney. Though studies on H₂S regulation of renal physiology and pathophysiology are still in its infancy, emerging evidence shows that H₂S production by renal cells is reduced under disease states and H₂S donors ameliorate kidney injury. Specifically, aberrant H₂S level is implicated in various renal pathological conditions including diabetic nephropathy. This review presents the roles of H₂S in diabetic renal disease and the underlying mechanisms for the protective effects of H₂S against diabetic renal damage. H₂S may serve as fundamental strategies to treat diabetic kidney disease. These H₂S treatment modalities include precursors for H₂S synthesis, H₂S donors, and natural plant-derived compounds. Despite accumulating evidence from experimental studies suggests the potential role of the H₂S signaling pathway in the treatment of diabetic nephropathy, these results need further clinical translation. Expanding understanding of H₂S in the kidney may be vital to translate H₂S to be a novel therapy for diabetic renal disease.

【 授权许可】

Unknown