Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells

Ecotoxicology and Environmental Safety

Yongjiang Ma¹  Wei Wei²  Rui Cao²  Mingjun Xiong²  Sitong Yao²  Lin Lu²  Shijin Liang²  Xiaohuan Liang²  Chen Zhang³ 

[1] Corresponding authors.;College of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou 510642, Guangdong, China;Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;

关键词: Zearalenone;    Decidualization;    Resveratrol;    Anti-oxidative stress;    Ecotoxicity;   

DOI  :  

来源: DOAJ

【 摘 要 】

Decidualization, which endows the endometrium competency to adopt developing embryo and maintain appropriate milieu for following growth, is a pivotal process for human pregnancy. The delicate collaboration between ovarian steroid hormones estrogen and progesterone governs the process of decidualization and subsequent establishment of embryo implantation. Mycotoxin zearalenone (ZEA) is well known as endocrine disruptor due to its potent estrogenic activity. In this study, we investigated effects of ZEA on decidualization of human endometrial stromal cells. Results indicated that ZEA exhibited its inhibitory action through nuclear translocation of ERα. ZEA exposure led to dampened progress of decidualization, which could be attenuated by estrogen receptor antagonist. Notably, resveratrol (RSV) administration restored impaired decidualization process by induction of anti-oxidative gene glutathione peroxidase 3 (GPX3). This study provides novel insights into the mechanism underlying adverse effects of ZEA in human decidual stromal cells and suggests RSV a potential therapeutic candidate to alleviate ZEA-induced cytotoxicity during decidualization.

【 授权许可】

Unknown