期刊论文详细信息
Frontiers in Psychiatry
A Clinical Rationale for Assessing the Impact of Childhood Sexual Abuse on Adjunctive Subcutaneous Esketamine for Treatment-Resistant Depression
Acioly Luiz Tavares Lacerda1  Hugo Cogo-Moreira2  Charles B. Nemeroff3  Lorena Catarina Del Sant4  Ana Cecília Lucchese4  Marco Aurélio Tuena4  Guilherme Abdo4  Carolina Nakahira4  Camila Brito Puertas4  Luciana Maria Sarin4  Victor Augusto Rodovalho Fava4  Matheus Ghossain Barbosa4  Eduardo Jorge Muniz Magalhães4  Juliana Surjan6  José Alberto Del Porto6  Rodrigo Simonini Delfino6  Matheus Souza Steglich6  Andrea Feijo Mello7 
[1] CNS Unit, BR Trials, São Paulo, Brazil;Department of Education, ICT and Learning, Faculty of Teacher Education and Languages, Østfold University College, Halden, Norway;Department of Psychiatry and Behavioral Sciences, Institute of Early Life Adversity Research, Dell Medical School, University of Texas at Austin, Austin, TX, United States;Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil;Laboratory of Integrative Neuroscience, Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil;Program for Care on Affective Disorders, Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil;Program for Research and Care on Violence and Post-traumatic Stress Disorder, Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil;
关键词: child sex abuse;    treatment-resistant depression;    esketamine;    sex;    directed acyclic graph;   
DOI  :  10.3389/fpsyt.2021.608499
来源: DOAJ
【 摘 要 】

Background: A history of child sexual abuse (CSA) is related to higher suicide rates and poor treatment outcomes in depressed adult patients. Twenty years after the first study investigating the effects of ketamine/esketamine on depression and suicide, there is a lack of data on the CSA effects on this emerging treatment. Here, we assess the impact of CSA on adjunctive subcutaneous (SC) esketamine for treatment-resistant depression (TRD).Methods: A directed acyclic graphic (DAG) was designed to identify clinical confounders between CSA and esketamine predictors of response. The confounders were applied in a statistical model to predict depression symptom trajectory in a sample of 67 TRD outpatients.Results: The patient sample had a relatively high prevalence rate of CSA (35.82%). Positive family history of first-degree relatives with alcohol use disorder and sex were clinical mediators of the effects of esketamine in a CSA adult population. Overall, the presence of at least one CSA event was unrelated to esketamine symptom reduction.Conclusions: Unlike responses to conventional antidepressants and psychotherapy, CSA does not appear to predict poor response to esketamine.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次