Menstruation-Related Disorders—Dysmenorrhea and Heavy Bleeding—as Significant Epiphenomena in Women With Rheumatic Diseases

Frontiers in Pharmacology

Gianluca Sambataro¹  Gemma Lepri²  Martina Orlandi²  Silvia Bellando-Randone²  Maria Ramona Melis²  Khadija El Aoufy²  Serena Guiducci²  Felice Petraglia³  Silvia Vannuccini³  Marco Matucci Cerinic⁴ 

[1] Artroreuma S.R.L., Rheumatology Outpatient Clinic Associated with the National Health System, Catania, Italy;Department of Experimental and Clinical Medicine, University of Florence and Division of Rheumatology AOUC and Scleroderma Unit, Florence, Italy;Obstetrics and Gynecology, Department of Maternity and Infancy, AOU Careggi Florence, Florence, Italy;Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Milan, Italy;

关键词: heavy menstrual bleeding;    menstruation disorders;    dysmenorrhea;    dyspareunia;    rheumatic and musculoskeletal disease;    gynecological diseases;   

DOI  :  10.3389/fphar.2022.807880

来源: DOAJ

【 摘 要 】

Background: In women with rheumatic diseases (RDs) menstruation-related disorders have never been investigated. The aim of this study was to evaluate gynecological symptoms/disorders in fertile age women with RDs.Materials and methods: All patients (n = 200) filled up a self-administered questionnaire on their gynecological history, menstrual cycle pattern, menstrual-related symptoms, and quality of life (QoL). The RD group was then compared to a control group of 305 age-matched fertile age women.Results: Among patients with RDs, 58% had arthritis, 40% connective tissue diseases (CTDs), and 1.5% systemic vasculitis. No differences were observed between CTDs and arthritis, except for a family history of HMB which was more common among women with CTDs (p < .01). When compared to controls, women with RDs reported more frequent heavy menstrual bleeding (HMB) during adolescence (51.7 and 25.4%, respectively; p = .0001) and adult life (37.7 and 25.9%, respectively; p = .0065). Also, dysmenorrhea in adolescence was significantly more common among cases (55.6 and 45.4%, respectively; p = .0338). Gynecological pain (dysmenorrhea, non-menstrual pelvic pain, dyspareunia, dysuria, and dyschezia) in patients with RDs was more frequent than in controls (p = .0001, .0001, .0001, .0001, .0002, respectively). Considering women who reported moderate and severe symptoms in RDs, dysmenorrhea and dyspareunia remain significantly more frequent in women with RDs than in controls (p = .0001; p = .0022; respectively). QoL scores were significantly reduced in women with RDs, either in physical (p = .0001) and mental domains (p = .0014) of short-form 12.Conclusion: Women affected by RDs frequently presented menstruation-related disorders; thus, female patients with RDs should be questioned about gynecological symptoms and referred to the gynecologist for an accurate evaluation.

【 授权许可】

Unknown