The Effects of Various Metallic Surfaces on Cellular and Bacterial Adhesion

Metals

Akiko Nagai¹  Haruka Ito²  Risa Yamada³  Masaya Shimabukuro³  Kosuke Nozaki³  Peng Chen⁴  Maki Ashida⁴  Takao Hanawa⁴  Yusuke Tsutsumi⁴ 

[1] Department of Anatomy, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto, Chikusa-ku, Nagoya 464-8650, Japan;Faculty of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan;Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan;Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan;

关键词: titanium;    niobium;    tantalum;    zirconium;    silver;    β-stabilizer elements;    antibacterial activity;    biocompatibility;    cytotoxicity;    biofilm;   

DOI  :  10.3390/met9111145

来源: DOAJ

【 摘 要 】

The effects of Ti, Nb, Ta, Zr, and Ag on cellular and bacterial adhesion were investigated in this study. Moreover, the relationships between surface compositions, metal ion release behaviors, and biological responses were examined. As a result, MC3T3-E1 cells and S. aureus were able to better attach to Ti and Zr rather than the Nb and Ta specimens. For the Ag specimen, the amount of Ag ions released into Hanks’ solution was the largest among all the specimens. Cellular and bacterial adhesion onto the Ag specimen was inhibited compared with the other specimens, because of Ag ion release. Alternatively, Nb and Ta specimens exhibited specific biological responses. Cellular adhesion on Nb and Ta specimens was similar to that on Ti, while bacterial adhesion on Nb and Ta specimens was inhibited compared with that on Ti. This study proved that Nb and Ta inhibited bacterial adhesion and exhibited no harmful effects on cellular adhesion. In addition, these results indicate that the passive layer on Nb and Ta plays a key role in the inhibition of bacterial adhesion.

【 授权许可】

Unknown