Reactivation of Herpes Simplex Virus Type 1 (HSV-1) Detected on Bronchoalveolar Lavage Fluid (BALF) Samples in Critically Ill COVID-19 Patients Undergoing Invasive Mechanical Ventilation: Preliminary Results from Two Italian Centers

Microorganisms

Denise Battaglini¹  Iole Brunetti¹  Chiara Dentone²  Laura Magnasco²  Roberto Luzzati³  Erik Roman-Pognuz³  Stefano Di Bella³  Luigi Principe⁴  Federica Briano⁵  Matteo Bassetti⁵  Giorgia Brucci⁵  Andrea De Maria⁵  Silvia Dettori⁵  Daniele Roberto Giacobbe⁵  Giancarlo Icardi⁵  Umberto Lucangelo⁶  Federica Friso⁶  Nicolò Patroniti⁷  Lorenzo Ball⁷  Paolo Pelosi⁷  Chiara Robba⁷  Bianca Bruzzone⁸  Giulia Guarona⁸  Verena Zerbato⁹  Riccardo Pol⁹  Ludovica Segat^1,10  Pierlanfranco D’Agaro^1,10 

[1] Anaesthesia and Intensive Care, San Martino Policlinico Hospital-IRCCS for Oncology and Neurosciences, 16132 Genoa, Italy;Clinica Malattie Infettive, San Martino Policlinico Hospital-IRCCS for Oncology and Neurosciences, 16132 Genoa, Italy;Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy;Clinical Pathology and Microbiology Unit, “San Giovanni di Dio” Hospital, 88900 Crotone, Italy;Department of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy;Department of Perioperative Medicine, Intensive Care and Emergency, Cattinara Hospital, Trieste University, 34149 Trieste, Italy;Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy;Hygiene Unit, San Martino Policlinico Hospital-IRCCS for Oncology and Neurosciences, 16132 Genoa, Italy;Infectious Diseases Unit, Trieste University Hospital, 34127 Trieste, Italy;Laboratorio di Riferimento per SARS-CoV-2, Regione Friuli-Venezia Giulia, Azienda Sanitaria Universitaria Integrata Giuliano-Isontina (ASUGI), UCO Igiene e Sanità Pubblica, 34127 Trieste, Italy;

关键词: HSV-1;    herpes simplex virus;    reactivation;    intensive care;    COVID-19;    SARS-CoV-2;   

DOI  :  10.3390/microorganisms10020362

来源: DOAJ

【 摘 要 】

Reactivation of herpes simplex virus type 1 (HSV-1) has been described in critically ill patients with coronavirus disease 2019 (COVID-19) pneumonia. In the present two-center retrospective experience, we primarily aimed to assess the cumulative risk of HSV-1 reactivation detected on bronchoalveolar fluid (BALF) samples in invasively ventilated COVID-19 patients with worsening respiratory function. The secondary objectives were the identification of predictors for HSV-1 reactivation and the assessment of its possible prognostic impact. Overall, 41 patients met the study inclusion criteria, and 12/41 patients developed HSV-1 reactivation (29%). No independent predictors of HSV-1 reactivation were identified in the present study. No association was found between HSV-1 reactivation and mortality. Eleven out of 12 patients with HSV-1 reactivation received antiviral therapy with intravenous acyclovir. In conclusion, HSV-1 reactivation is frequently detected in intubated patients with COVID-19. An antiviral treatment in COVID-19 patients with HSV-1 reactivation and worsening respiratory function might be considered.

【 授权许可】

Unknown