Advances in Diagnosis, Surveillance, and Monitoring of Zika Virus: An Update

Frontiers in Microbiology

Kumaragurubaran Karthik¹  Ashok Munjal²  Rekha Khandia²  Ruchi Tiwari³  Yashpal S. Malik⁴  Kuldeep Dhama⁵  Raj K. Singh⁶  Rubén Bueno-Marí⁷  Hafiz M. N. Iqbal⁸ 

[1] Central University Laboratory, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India;Department of Biochemistry and Genetics, Barkatullah University, Bhopal, India;Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan, Mathura, India;Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, India;Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India;ICAR-Indian Veterinary Research Institute, Bareilly, India;Laboratorios Lokímica, Departamento de Investigación y Desarrollo (I+D), Valencia, Spain;School of Engineering and Science, Tecnologico de Monterrey, Monterrey, Mexico;

关键词: Zika virus;    Zika fever;    diagnosis;    surveillance;    monitoring;   

DOI  :  10.3389/fmicb.2017.02677

来源: DOAJ

【 摘 要 】

Zika virus (ZIKV) is associated with numerous human health-related disorders, including fetal microcephaly, neurological signs, and autoimmune disorders such as Guillain-Barré syndrome (GBS). Perceiving the ZIKA associated losses, in 2016, the World Health Organization (WHO) declared it as a global public health emergency. In consequence, an upsurge in the research on ZIKV was seen around the globe, with significant attainments over developing several effective diagnostics, drugs, therapies, and vaccines countering this life-threatening virus at an early step. State-of-art tools developed led the researchers to explore virus at the molecular level, and in-depth epidemiological investigations to understand the reason for increased pathogenicity and different clinical manifestations. These days, ZIKV infection is diagnosed based on clinical manifestations, along with serological and molecular detection tools. As, isolation of ZIKV is a tedious task; molecular assays such as reverse transcription-polymerase chain reaction (RT-PCR), real-time qRT-PCR, loop-mediated isothermal amplification (LAMP), lateral flow assays (LFAs), biosensors, nucleic acid sequence-based amplification (NASBA) tests, strand invasion-based amplification tests and immune assays like enzyme-linked immunosorbent assay (ELISA) are in-use to ascertain the ZIKV infection or Zika fever. Herein, this review highlights the recent advances in the diagnosis, surveillance, and monitoring of ZIKV. These new insights gained from the recent advances can aid in the rapid and definitive detection of this virus and/or Zika fever. The summarized information will aid the strategies to design and adopt effective prevention and control strategies to counter this viral pathogen of great public health concern.

【 授权许可】

Unknown