Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model

Pharmaceuticals

Jeonghyun Kim¹  Eunkuk Park¹  Hyoju Jeon¹  SeungHee Yun¹  Seon-Yong Jeong¹  ChangGun Lee¹  Seokjin Hwang¹  Subin Yeo²  Hyesoo Jeong²  Seong-Hoon Yun² 

[1] Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, Korea;Nine B Co. Ltd., Daejeon 34121, Korea;

关键词: arthritis;    Cornus officinalis;    loganin;    destabilization of the medial meniscus;    anti-inflammatory effect;   

DOI  :  10.3390/ph14020135

来源: DOAJ

【 摘 要 】

Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from Cornus officinalis (CO) extract to screen for anti-arthritic effects. A single component, loganin, was identified as a candidate. The CO extract and loganin inhibited the expression of factors associated with cartilage degradation, such as cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte inflammation. In addition, prostaglandin and collagenase levels were reduced following treatment of IL-1β-induced chondrocytes with loganin. In the destabilization of the medial meniscus (DMM)-induced mouse model, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT images revealed that loganin reduced DMM-induced osteophyte formation. These results indicate that loganin has protective effects in DMM-induced mice.

【 授权许可】

Unknown