Dietary supplementation with okara and Bacillus coagulans lilac-01 improves hepatic lipid accumulation induced by cholic acids in rats

Journal of Functional Foods

Yasutake Tanaka¹  Takuma Nose²  Satoshi Ishizuka³  Wakana Iwasaki⁴  Kazunori Miwa⁵  Hidehisa Shimizu⁶  Taketo Hanai⁶  Kimiko Minamida⁶  Ga-Hyun Joe⁶  Shota Hori⁶  Fumika Yokoyama⁶  Misaki Tsuji⁶  Koji Tada⁶  Yeonmi Lee⁶ 

[1] Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155, Gaetbeol-ro, Yeonsu-gu, Incheon 21999, South Korea;Research Faculty of Fisheries, Hokkaido University, Hakodate 041-8611, Japan;Arterio Bio Co, Ltd, Otaru 047-0261, Japan;Faculty of Agriculture, Kyushu University, Fukuoka 819-0385, Japan;Faculty of Life and Environmental Science, Shimane University, Matsue 690-8504, Japan;Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan;

关键词: Symbiotic;    Hepatic lipid accumulation;    Cholic acid;    Okara;    Rats;   

DOI  :  

来源: DOAJ

【 摘 要 】

A dietary symbiotic supplement of okara, a by-product of tofu manufacturing with Bacillus coagulans lilac-01 found to reduce secondary bile acid (BA) in a rat study and cholic acid (CA), a primary 12α-hydroxylated (12αOH) BA, induces lipid accumulation in rats. In this study, we investigated whether dietary supplementation of a synbiotic with okara and Bacillus coagulans lilac-01 improves CA-induced hepatic lipid accumulation. Male Wistar/ST rats (4 weeks old) were fed with or without CA-supplementation combined with the synbiotic for 2 weeks. The CA diet increased hepatic triglycerides and the synbiotic diet in combination with CA normalized liver triglyceride concentration accompanied by suppression of hepatic fatty acid synthase expression, enhancement of fecal triglyceride excretion, and increase in fecal non-12αOH BA excretion. Dietary supplementation with the okara synbiotic ameliorated hepatic lipid accumulation probably by reducing de novo lipogenesis and enhancing fecal triglyceride excretion.

【 授权许可】

Unknown