Astrocytic Regulation of Neural Circuits Underlying Behaviors

Cells

Hyosang Lee¹  Sun-Nyoung Hwang¹  Kain Seo²  Jae Seung Lee² 

[1] Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea;Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Korea;

关键词: astrocyte;    neural circuit;    behavior;    GFAP;    chemogenetics;    optogenetics;   

DOI  :  10.3390/cells10020296

来源: DOAJ

【 摘 要 】

Astrocytes, characterized by a satellite-like morphology, are the most abundant type of glia in the central nervous system. Their main functions have been thought to be limited to providing homeostatic support for neurons, but recent studies have revealed that astrocytes actually actively interact with local neural circuits and play a crucial role in information processing and generating physiological and behavioral responses. Here, we review the emerging roles of astrocytes in many brain regions, particularly by focusing on intracellular changes in astrocytes and their interactions with neurons at the molecular and neural circuit levels.

【 授权许可】

Unknown