Gene Expression Profiling of Early Acute Febrile Stage of Dengue Infection and Its Comparative Analysis With Streptococcus pneumoniae Infection

Frontiers in Cellular and Infection Microbiology

Shabana Parveen¹  Leena H. Bajrai²  Ahmad Firoz³  Muddassir Reyaz⁴  Sayed S. Sohrab⁵  Thamir A. Alandijany⁵  Esam I. Azhar⁵  Mohammad A. Kamal⁶  Mohammad Mobashir⁸ 

[1] 0Department of Bioscience, Jamia Millia Islamia, New Delhi, India;Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia;Department of Healthcare Management, Jamia Hamdard Hamdard Nagar, New Delhi, India;Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;Enzymoics, Novel Global Community Educational Foundation, Hebersham, NSW, Australia;King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;SciLifeLab, Department of Oncology and Pathology Karolinska Institutet, Stockholm, Sweden;Special Infectious Agents Unit – BSL-3, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia;West China School of Nursing/Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China;

关键词: dengue virus;    Streptococcus pneumoniae;    pathogenesis;    gene expression;    innate immunity;    dengue hemorrhagic fever;   

DOI  :  10.3389/fcimb.2021.707905

来源: DOAJ

【 摘 要 】

Infectious diseases are the disorders caused by organisms such as bacteria, viruses, fungi, or parasites. Although many of them are permentantly hazardous, a number of them live in and on our bodies and they are normally harmless or even helpful. Under certain circumstances, some organisms may cause diseases and these infectious diseases may be passed directly from person to person or via intermediate vectors including insects and other animals. Dengue virus and Streptococcus pneumoniae are the critical and common sources of infectious diseases. So, it is critical to understand the gene expression profiling and their inferred functions in comparison to the normal and virus infected conditions. Here, we have analyzed the gene expression profiling for dengue hemorrhagic fever, dengue fever, and normal human dataset. Similar to it, streptococcus pneumoniae infectious data were analyzed and both the outcomes were compared. Our study leads to the conclusion that the dengue hemorrhagic fever arises in result to potential change in the gene expression pattern, and the inferred functions obviously belong to the immune system, but also there are some additional potential pathways which are critical signaling pathways. In the case of pneumoniae infection, 19 pathways were enriched, almost all these pathways are associated with the immune system and 17 of the enriched pathways were common with dengue infection except platelet activation and antigen processing and presentation. In terms of the comparative study between dengue virus and Streptococcus pneumoniae infection, we conclude that cell adhesion molecules (CAMs), MAPK signaling pathway, natural killer cell mediated cytotoxicity, regulation of actin cytoskeleton, and cytokine-cytokine receptor interaction are commonly enriched in all the three cases of dengue infection and Streptococcus pneumoniae infection, focal adhesion was enriched between classical dengue fever — dengue hemorrhagic fever, dengue hemorrhagic fever—normal samples, and SP, and antigen processing and presentation and Leukocyte transendothelial migration were enriched in classical dengue fever —normal samples, dengue hemorrhagic fever—normal samples, and Streptococcus pneumoniae infection.

【 授权许可】

Unknown