EEG Dynamics of a Go/Nogo Task in Children with ADHD

Brain Sciences

Cecile Colin¹  Bernard Dan²  Nicolas Deconinck²  Simon Baijot²  David Zarka³  Carlos Cevallos³  Axelle Leroy³  Guy Cheron³  Hichem Slama⁴ 

[1] Cognitive Neurosciences Research Unit, Center for Research in Cognition and Neurosciences, Université Libre de Bruxelles, 1050 Brussels, Belgium;Department of Neurology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, 1020 Brussels, Belgium;Laboratory of Neurophysiology and Movement Biomechanics, Université Libre de Bruxelles, CP640, 808 route de Lennik, 1070 Brussels, Belgium;Neuropsychology and Functional Neuroimaging Research Unit, Center for Research in Cognition and Neurosciences, Université Libre de Bruxelles, 1050 Brussels, Belgium;

关键词: ADHD;    Go/Nogo;    EEG;    brain oscillations;    rhythms;    ERP;    ERSP;    ITC;   

DOI  :  10.3390/brainsci7120167

来源: DOAJ

【 摘 要 】

Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). However, the electroencephalographic (EEG) dynamics underlying these ERPs remain largely unexplored in ADHD. Methods: We investigate the event-related spectral perturbation and inter-trial coherence linked to the ERP triggered by visual Cue-Go/NoGo stimuli, in 14 children (7 ADHD and 7 TDC) aged 8 to 12 years. Results: Compared to TDC, the EEG dynamics of children with ADHD showed a lower theta-alpha ITC concomitant to lower occipito-parietal P1-N2 and frontal N1-P2 potentials in response to Cue, Go and Nogo stimuli; an upper alpha power preceding lower central Go-P3; a lower theta-alpha power and ITC were coupled to a lower frontal Nogo-N3; a lower low-gamma power overall scalp at 300 ms after Go and Nogo stimuli. Conclusion: These findings suggest impaired ability in children with ADHD to conserve the brain oscillations phase associated with stimulus processing. This physiological trait might serve as a target for therapeutic intervention or be used as monitoring of their effects.

【 授权许可】

Unknown