Investigation for biomechanical and biochemical characteristic changes of kidney, liver and duodenum tissues according to inflation time of REBOA

Materials & Design

Up Huh¹  Chi-Seung Lee²  Il Jae Wang³  Seungik Baek⁴  Dongman Ryu⁵ 

[1] Department of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, United States;Department of Emergency Medicine, School of Medicine, Pusan National University, and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea;Department of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, United States;Department of Thoracic and Cardiovascular Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea;Medical Research Institute, Pusan National University, Busan 49241, Republic of Korea;

关键词: Resuscitative Endovascular Balloon Occlusion of Aorta;    Blood Test;    Inflation Time;    Mechanical Property;    Compression Test;    Uniaxial Tensile Test;   

DOI  :  

来源: DOAJ

【 摘 要 】

In the study on emergency treatment of massive hemorrhage, it is important to investigate the duration of inflation time in resuscitative endovascular balloon occlusion of aorta (REBOA). REBOA temporarily controls bleeding and maintains the blood pressure while causing side effects to the other organs. To elucidate the side effects of REBOA on the main organs and establish their clinical criteria, both mechanical behavior and clinical examination of each organ tissue must be characterized based on the operation time. Particularly, two rate-dependent mechanical tests (tensile and compression tests) and tissue blood tests (blood urea nitrogen, creatinine, aspartate aminotransferase, and lactate tests) of the kidney, liver, and duodenum tissues were examined according to the inflation time of REBOA. Finally, it was demonstrated that the characteristic of the soft tissue by the loading rate was maintained even in the ischemic tissue. In addition, based on the presented results, it was confirmed that the inflation time of REBOA have an effect on the variation in properties of several organ tissues.

【 授权许可】

Unknown