Somatostatin Analogs in Clinical Practice: A Review

International Journal of Molecular Sciences

Jersy Cárdenas-Salas¹  Cristina Álvarez-Escolá²  Mariana Gomes-Porras² 

[1] Department of Endocrinology, “Fundación Jiménez-Diaz” University Hospital. Av. de los Reyes Católicos, 2, 28040 Madrid, Spain;Department of Endocrinology, “La Paz” University Hospital. Paseo de la Castellana, 261, 28046 Madrid, Spain;

关键词: somatostatin analog;    pituitary adenoma;    neuroendocrine tumor;    cancer;    carcinoid;    lanreotide;    octreotide;    pasireotide;   

DOI  :  10.3390/ijms21051682

来源: DOAJ

【 摘 要 】

Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors. They should also be considered an effective and safe therapeutic alternative to corticotropinomas, gonadotropinomas, and prolactinomas resistant to dopamine agonists. Somatostatin analogs have also shown to be useful in the treatment of other endocrine diseases (congenital hyperinsulinism, Graves’ orbitopathy, diabetic retinopathy, diabetic macular edema), non-endocrine tumors (breast, colon, prostate, lung, and hepatocellular), and digestive diseases (chronic refractory diarrhea, hepatorenal polycystosis, gastrointestinal hemorrhage, dumping syndrome, and intestinal fistula).

【 授权许可】

Unknown