Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers

Advanced Intelligent Systems

Ya Xiong¹  Yueqiang Lin¹  Ye Niu¹  Lin Qi¹  Yi Zhao¹  Qingzhong Xue² 

[1] Department of Biomedical Engineering The Ohio State University Columbus OH 43210 USA;Department of Materials Science and Engineering China University of Petroleum Qingdao 266580 Shandong P. R. China;

关键词: autonomous drug administration;    biophysical properties;    controlled drug release;    hydrogels;    nanocarriers;    smart systems;   

DOI  :  10.1002/aisy.201900124

来源: DOAJ

【 摘 要 】

Many biophysical and biochemical properties of pathogenic tissues are different from those of healthy tissues. These disease symptom‐associated properties include pH, reduction–oxidation conditions, enzyme generation and expression, blood glucose concentration, mechanical stiffness and strain, and temperature. Autonomous drug release that uses one or more of these disease symptom‐associated properties as the release trigger minimizes the delay in treatments and allows for the release of medications with precisely controlled amounts and with desired spatiotemporal patterns. Herein, a comprehensive assessment of current research progress on autonomous drug release systems (ADRS) is provided. The representative symptoms‐associated properties that can be potentially used as the endogenous stimuli are introduced. The autonomous drug systems that utilize these symptom‐associated signals as the endogenous stimulation signals are discussed, followed by the discussion of current challenges and opportunities in this field, as well as possible future directions in ADRS.

【 授权许可】

Unknown