Association Between Dietary Intake of One-Carbon Metabolism-Related Nutrients and Fluorosis in Guizhou, China

Frontiers in Nutrition

Xun Zhao¹  Donghong Wang²  Na Tao³  Dafang Cao⁴  Jun Liu⁴  Ting Chen⁴  Sheng Yang⁵ 

[1] Department of Chronic Diseases, Center for Diseases Control and Prevention of Zhijin County, Zhijin, China;Department of Gynaecology and Obstetrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China;Department of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi, China;Department of Preventive Medicine, School of Public Health, Zunyi Medical University, Zunyi, China;Department of Surveillance in Public Health, Center for Disease Control and Prevention of Renhuai City, Renhuai, China;

关键词: one-carbon metabolism;    fluorosis;    dietary;    betaine;    choline;    methionine;   

DOI  :  10.3389/fnut.2021.700726

来源: DOAJ

【 摘 要 】

Objective: This study aimed to investigate the associations between dietary one-carbon metabolism-related nutrients (betaine, choline, methionine, folate, vitamin B6, and vitamin B12) and fluorosis among the Chinese population in an area known for coal-burning fluorosis.Methods: A cross-sectional study was conducted, with 653 fluorosis patients and 241 non-fluorosis participants. Dietary intake was acquired using a validated semi-quantitative 75-item food frequency questionnaire. The risk associations were assessed by unconditional logistical regression.Results: We observed a significant inverse association between dietary betaine, total choline, methionine, folate, vitamin B6, and choline species and fluorosis. The adjusted OR (95% CI) in the highest quartile of consumption compared with the lowest were 0.59 (0.37–0.94) (P-trend = 0.010) for betaine intake, 0.45 (0.28–0.73) (P-trend = 0.001) for total choline intake, 0.45 (0.28–0.72) (P-trend < 0.001) for methionine intake, 0.39 (0.24–0.63) (P-trend < 0.001) for folate intake, 0.38 (0.24–0.62) (P-trend < 0.001) for vitamin B6 intake, and 0.46 (0.28–0.75) (P-trend = 0.001) for total choline plus betaine intake. Dietary intakes of choline-containing compounds, phosphatidylcholine, free choline, glycerophosphocholine, and phosphocholine were also inversely associated with lower fluorosis (all P-trend < 0.05). No significant associations were observed between dietary vitamin B12 or sphingomyelin and fluorosis.Conclusion: The present study suggested that the higher dietary intakes of specific one-carbon metabolism-related nutrients, such as betaine, choline, methionine, folate, and vitamin B6, are associated with lower fluorosis prevalence.

【 授权许可】

Unknown