Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states

Onkogematologiâ

F. I. Ataullakhanov¹  E. N. Lipets²  M. A. Panteleev² 

[1] Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences;Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev;

关键词: global assays of hemostasis;    hypercoagulation;    thrombosis;    activated partial thromboplastin time;    thrombin generation;    thrombelastography;    thrombodynamics;    cancer;    pregnancy;    diabetes mellitus;   

DOI  :  10.17650/1818-8346-2015-10-3-78-91

来源: DOAJ

【 摘 要 】

In the second part we present a review of the existing data about ability of integrated tests, as already introduced in clinical practice, and the new (test of thrombin generation, thromboelastography, thrombodynamics, perfusion chamber) to assess the risk of thrombosis in different pathologies. We can conclude that the existing integrated tests can be an important tool in the diagnosis of hypercoagulation. However, lack of standardization prevents their use: various tests and modifications of each test are different in sensitivity and specificity for each pathological condition. Furthermore, even in situations where the tests can reliably identify a group of patients with different degrees of thrombosis risk, their use in clinical practice is often difficult, since the differences between these groups were statistically significant, but the normal range and patients significantly overlap.

【 授权许可】

Unknown