Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment and Future Directions

Biomedicines

BrandonD. Philbrick¹  D.Cory Adamson¹  Christian Ogasawara² 

[1] Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA;Department of Surgery, University of Hawaii School of Medicine, Honolulu, HI 96813, USA;

关键词: meningioma;    central nervous system;    tumor;    benign;    malignant;   

DOI  :  10.3390/biomedicines9030319

来源: DOAJ

【 摘 要 】

Meningiomas are the most common intracranial tumor, making up more than a third of all primary central nervous system (CNS) tumors. They are mostly benign tumors that can be observed or preferentially treated with gross total resection that provides good outcomes. Meningiomas with complicated histology or in compromising locations has proved to be a challenge in treating and predicting prognostic outcomes. Advances in genomics and molecular characteristics of meningiomas have uncovered potential use for more accurate grading and prediction of prognosis and recurrence. With the study and detection of genomic aberrancies, specific biologic targets are now being trialed for possible management of meningiomas that are not responsive to standard surgery and radiotherapy treatment. This review summarizes current epidemiology, etiology, molecular characteristics, diagnosis, treatments, and current treatment trials.

【 授权许可】

Unknown