The Antidepressant Effect of Deoiled Sunflower Seeds on Chronic Unpredictable Mild Stress in Mice Through Regulation of Microbiota–Gut–Brain Axis

Frontiers in Nutrition

Long Jin¹  Ce Qi¹  Jie Zheng²  Xiaomeng Lu³  Mei Sun³  Jin Sun³ 

[1] D Center for Nuts Processing Technology, Qiaqia Food Co., Ltd., Hefei, China;Institute of Nutrition and Health, Qingdao University, Qingdao, China;;National R&

关键词: deoiled and dechlorogenic acid sunflower seeds;    antidepressant;    chronic unpredictable mild stress;    oxidative stress;    intestinal mucosal barrier;    gut microbiota;   

DOI  :  10.3389/fnut.2022.908297

来源: DOAJ

【 摘 要 】

ObjectivesSunflower seeds provide tryptophan-rich proteins with the potential to protect against depression. Tryptophan is a precursor of serotonin and a substrate for the production of indole derivatives by gut microbiota. This study aimed to investigate the association between the depression-alleviating effects of deoiled and dechlorogenic sunflower seeds (DSFS) and regulation of gut microbiota.Materials and MethodsMale C57BL/6J mice were fed a diet comprising a source of soy protein (normal and model control), DSFS or whey protein concentrate (positive control) for 7 weeks, and chronic stress-induced depression was induced.ResultsFeeding the DSFS diet prevented depression-like behaviors, intestinal barrier damage, elevated plasma corticosterone, and reduced hippocampal serotonin levels in mice. Meanwhile, Feeding the DSFS diet significantly altered the gut microbiota structure, characterized by elevated relative abundances of Ileibacterium valens, Ruminococcus flavefaciens, Clostridium scindens, and Olsenella massiliensis, which were inversely associated with depressive behaviors and markers of mucosal barrier damage. DSFS also altered the gut metabolite profile, prevented depression-induced gut L-tryptophan depletion, and upregulated its metabolite indoleacetaldehyde.ConclusionFeeding the DSFS diet prevented depression in mice by remodeling the gut microbiota and bacterial tryptophan metabolism.

【 授权许可】

Unknown