The Acid–Base Balance and Gender in Inflammation: A Mini-Review

Frontiers in Immunology

Jean Duchateau¹  Mustapha Chamekh¹  Georges Jacques Casimir¹  Nicolas Lefèvre²  Francis Corazza² 

[1] Laboratoire académique de Pédiatrie, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium;Laboratoire de Médecine translationnelle, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium;

关键词: inflammation;    homeostatic balance;    neutrophils;    monocytes;    endothelial cells;    gender differences;   

DOI  :  10.3389/fimmu.2018.00475

来源: DOAJ

【 摘 要 】

In humans, acid–base balance is crucial to cell homeostasis. Acidosis is observed in numerous inflammatory processes, primarily acute conditions such as sepsis, trauma, or acute respiratory distress where females tend to exhibit better prognosis compared with males. The mechanisms underlying these gender-dependent differences are multiple, probably involving hormonal and genetic factors, particularly the X chromosome. Although pH influences multiple immunological functions, gender differences in acid–base balance have been poorly investigated. In this review, we provide an update on gender differences in human susceptibility to inflammatory diseases. We additionally discuss the potential impact of acid–base balance on the gender bias of the inflammatory response in view of our recent observation that girls present higher neutrophilic inflammation and lower pH with a trend toward better prognosis in severe sepsis. We also highlight the potent role played by endothelial cells in gender differences of inflammation through activation of proton-sensing G protein-coupled receptors.

【 授权许可】

Unknown