Myocardial Flow Reserve Measurement During CZT-SPECT Perfusion Imaging for Coronary Artery Disease Screening: Correlation With Clinical Findings and Invasive Coronary Angiography—The CFR-OR Study

Frontiers in Medicine

Denis Angoulvant²  Gilles Metrard³  Frédérique Thibault³  Matthieu Bailly³  Maxime Courtehoux⁴  Maria Joao Ribeiro⁵ 

[1] Cardiology Department, CHRU TOURS, Tours, France;EA4245 T2i, Tours University, Tours, France;Nuclear Medicine Department, CHR ORLEANS, Orleans, France;Nuclear Medicine Department, CHRU TOURS, Tours, France;UMR 1253, iBrain, Université de Tours, Inserm, Tours, France;

关键词: myocardial blood flow;    myocardial flow reserve;    CZT-SPECT;    cardiovascular risk;    invasive coronary angiography;   

DOI  :  10.3389/fmed.2021.691893

来源: DOAJ

【 摘 要 】

Purpose: The aim of this study was to assess the results of cadmium zinc telluride (CZT)- single-photon emission computed tomography (SPECT) myocardial flow reserve (MFR) in coronary artery disease (CAD) screening regarding clinical risk and its correlation to invasive coronary angiography (ICA).Methods: A total of 137 patients (61 male and 76 female) referred for CAD screening myocardial perfusion imaging (MPI) between November 2018 and April 2020 were included in the CFR-OR prospective trial. The 10-year risk of cardiovascular death according to the European Society of Cardiology (SCORE) was calculated. SPECT 1-day 99mTc-tetrofosmin protocol was acquired on CZT cardiac-dedicated pinhole cameras. Low-dose thoracic CT was used for coronary calcium score (CCS) evaluation. ICA, when performed within 3 months, was also analyzed.Results: Mean SCORE and mean global MFR were, respectively, 4 ± 3.1% and 2.50 ± 0.74; 34 patients had impaired CFR (using a threshold of 2). There was a significant inverse correlation between MFR and SCORE (p = 0.006), gender (p = 0.019), and number of cardiovascular risk factors (p = 0.01). MFR was significantly reduced in patients with CCS above 1 (p = 0.01). No significant correlation was found between MFR and individual cardiovascular risk factors (dyslipidemia, hypertension, diabetes, or family history of CAD). A total of 23 patients underwent ICA. Global MFR SPECT sensitivity and specificity were 83.3 and 100 %, respectively, with an area under the curve of 0.94.Conclusion: Adding MFR to SPECT MPI for CAD screening on CZT camera may contribute to high-risk patient identification and enhance diagnostic performances. MFR could help physician decision to perform ICA.

【 授权许可】

Unknown