Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases

Vaccines

GimanoD. Amatngalim¹  AnneM. van der Does²  PieterS. Hiemstra²  Remi Villenave³  Bart Keijser⁴ 

[1] Department of Pediatric Pulmonology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht 3508 AB, The Netherlands;Department of Pulmonology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands;Emulate Inc., Boston, MA 02210, USA;Research Group Microbiology and Systems Biology, TNO (The Netherlands Organization for Applied Scientific Research), Zeist 3704 HE, The Netherlands;

关键词: chronic inflammatory lung diseases;    COPD;    Asthma;    cystic fibrosis;    microbiota;    host defence peptides;    host-microbiota interactions;   

DOI  :  10.3390/vaccines6030049

来源: DOAJ

【 摘 要 】

The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of novel therapeutic strategies aimed at restoring host-microbiota homeostasis. In this review, we discuss recent literature on host-microbiota interactions in the respiratory tract, with a specific focus on the influence of endogenous host defence peptides and proteins (HDPs) on the composition of microbiota populations in vivo and explore possible HDPs-related therapeutic approaches targeting microbiota dysbiosis in chronic inflammatory lung diseases.

【 授权许可】

Unknown