Chronic Ultraviolet Irradiation to the Skin Dysregulates Adrenal Medulla and Dopamine Metabolism In Vivo

Antioxidants

Kyeong-No Yoon¹  Jin Ho Chung¹  Dong Hun Lee¹  Yong-Seok Lee²  Hye-Sun Lim³  Gunhyuk Park³ 

[1] Department of Biomedical Sciences, Graduate School, Seoul National University, Seoul 03080, Korea;Department of Physiology, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea;Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111 Geonjae-ro, Naju 58245, Korea;

关键词: UVB;    adrenal glands;    chromaffin cell;    dopamine;    DβH;    oxidative damage;   

DOI  :  10.3390/antiox10060920

来源: DOAJ

【 摘 要 】

Ultraviolet (UV) radiation has a strong biological effect on skin biology, and it switches on adaptive mechanisms to maintain homeostasis in organs such as the skin, adrenal glands, and brain. In this study, we examined the adaptation of the body to repeated bouts of UVB radiation, especially with respect to the catecholamine synthesis pathway of the adrenal glands. The effects of UVB on catecholamine-related enzymes were determined by neurochemical and histological analyses. To evaluate catecholamine changes after chronic excessive UVB irradiation of mouse skin, we examined dopamine and norepinephrine levels in the adrenal glands and blood from UV-irradiated and sham-irradiated mice. We found that chronic excessive UVB exposure significantly reduced dopamine levels in both tissues but did not affect norepinephrine levels. In addition, UVB irradiation significantly increased the levels of related enzymes tyrosine hydroxylase and dopamine-β-hydroxylase. Furthermore, we also found that apoptosis-associated markers were increased and that oxidative defense proteins were decreased, which might have contributed to the marked structural abnormalities in the adrenal medullas of the chronically UVB-irradiated mice. This is the first evidence of the damage to the adrenal gland and subsequent dysregulation of catecholamine metabolism induced by chronic exposure to UVB.

【 授权许可】

Unknown