Plant-Derived Antimicrobial Peptides as Potential Antiviral Agents in Systemic Viral Infections

Pharmaceuticals

on behalf of the OEMONOM¹  Ysaline Krier²  Quentin Albert³  Nour Mammari⁴  Mihayl Varbanov⁴  Marc Devocelle⁵ 

[1] ;Faculté de Pharmacie, 7 Avenue de la Foret de Haye, 54505 Vandoeuvre-Les-Nancy, France;Fungal Biodiversity and Biotechnology, INRAE/Aix-Marseille University, UMR1163, 13009 Marseille, France;L2CM, Université de Lorraine, CNRS, F-54000 Nancy, France;SSPC (SFI Research Centre for Pharmaceuticals), V94T9PX Limerick, Ireland;

关键词: antiviral peptides;    systemic infection;    virus;    natural compounds;    plants;   

DOI  :  10.3390/ph14080774

来源: DOAJ

【 摘 要 】

Numerous studies have led to a better understanding of the mechanisms of action of viruses in systemic infections for the development of prevention strategies and very promising antiviral therapies. Viruses still remain one of the main causes of human diseases, mainly because the development of new vaccines is usually challenging and drug resistance has become an increasing concern in recent decades. Therefore, the development of potential antiviral agents remains crucial and is an unmet clinical need. One abundant source of potential therapeutic molecules are plants: they biosynthesize a myriad of compounds, including peptides which can have antimicrobial activity. Our objective is to summarize the literature on peptides with antiviral properties derived from plants and to identify key features of these peptides and their application in systemic viral infections. This literature review highlights studies including clinical trials which demonstrated that plant cyclotides have the ability to inhibit the growth of viruses causing human diseases, defensin-like peptides possess anti-HIV-1 activity, and lipid transfer proteins and some lectins exhibit a varied antimicrobial profile. To conclude, plant peptides remain interesting to explore in the context of emerging and re-emerging infectious diseases.

【 授权许可】

Unknown