Incorporation of hydroxyapatite in crosslinked gelatin/chitosan/poly(vinyl alcohol) hybrids utilizing as reinforced composite sponges, and their water absorption ability

Progress in Natural Science: Materials International

Tran Thi Bich Chau Vo¹  Truong Sinh Nguyen²  Nhan Duy Pham³  Thi Sinh Vo³ 

[1] Corresponding author.;Department of Industrial Management, Can Tho University, Can Tho, Viet Nam;School of Mechanical Engineering, Sungkyunkwan University, Suwon, 16419, South Korea;

关键词: Reinforced composite sponge;    Gelatin;    Chitosan;    Poly(vinyl alcohol);    Hydroxyapatite;    Water absorption ability;   

DOI  :  

来源: DOAJ

【 摘 要 】

The crosslinked gelatin/chitosan/poly(vinyl alcohol)/hydroxyapatite (GEL/CTS/PVA/HAp, GCPH) sponges were fabricated by a freeze-drying method to yield the reinforced composite sponges with proper features. The porosity value and pore size of the crosslinked GCPH sponges reached ∼80% and 50–100 ​μm, respectively, which can be an appropriate range to allow cells to migrate into the reinforced composite sponges in the tissue engineering technology. Besides, the proper bonding presence between HAp particles and the crosslinked polymeric matrix or the crosslinked network formation between the polymers were also proved through fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermal gravimetric (TG/DTG) analysis. Owing to incorporation of HAp particles and good distribution of HAp particles inside the crosslinked polymeric matrix, their mechanical properties were improved through the determination of compression tests. Concomitantly, their water absorption ability reached effectively in both the distilled water and NaCl solution, and their recovery also maintained well for 10 absorbing–squeezing cycles to be considered as an effective reusability for the crosslinked sponge system. Thereby, the crosslinked GCPH sponge prepared in the present study can become a potential candidate to apply especially in the biomedical/medical applications and tissue engineering technology.

【 授权许可】

Unknown