Hydrogels for Exosome Delivery in Biomedical Applications

Gels

Qiuyue Guan¹  Yijia Yin²  Xianglong Han²  Yilin Chen²  Yaxin Xie²  Jiusi Guo² 

[1] Department of Geriatrics, People’s Hospital of Sichuan Province, Chengdu 610041, China;State Key Laboratory of Oral Diseases, Department of Orthodontics, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;

关键词: composite hydrogel;    exosome;    biomedical engineering;   

DOI  :  10.3390/gels8060328

来源: DOAJ

【 摘 要 】

Hydrogels, which are hydrophilic polymer networks, have attracted great attention, and significant advances in their biological and biomedical applications, such as for drug delivery, tissue engineering, and models for medical studies, have been made. Due to their similarity in physiological structure, hydrogels are highly compatible with extracellular matrices and biological tissues and can be used as both carriers and matrices to encapsulate cellular secretions. As small extracellular vesicles secreted by nearly all mammalian cells to mediate cell–cell interactions, exosomes play very important roles in therapeutic approaches and disease diagnosis. To maintain their biological activity and achieve controlled release, a strategy that embeds exosomes in hydrogels as a composite system has been focused on in recent studies. Therefore, this review aims to provide a thorough overview of the use of composite hydrogels for embedding exosomes in medical applications, including the resources for making hydrogels and the properties of hydrogels, and strategies for their combination with exosomes.

【 授权许可】

Unknown