Heliyon | |
Measuring Earwax Cortisol Concentration using a non-stressful sampling method | |
Lorena Ortega1  Allan H. Young2  Rodrigo Sandoval3  Jan Benöhr3  Alexander Hayes4  Anthony Cleare5  Susana Espinoza5  Andres Herane-Vives6  | |
[1] Affective Disorders Research Group, Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology &Corresponding author.;Neuroscience, King's College London, London, UK;;Affective Disorders Research Group, Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology &Departamento de Clínicas, Facultad de Medicina, Universidad Católica del Norte, Coquimbo, Chile;Institute of Cognitive Neuroscience, University College London, UK; | |
关键词: Psychiatry; Biological psychiatry; Depression; Endocrinology; Endocrine system; Metabolism; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Background: “Short-term” samples are not the most appropriate for reflecting chronic cortisol concentration. Although hair is used for reflecting the systemic level of this hormone, its use as a “long-term” measure appears clinically problematic. Local and systemic stress and non-stress related factors may release cortisol that is accumulated in hair. Non-stressful earwax sampling methods may provide a more accurate specimen to measure chronic cortisol concentration. Methods: Earwax from both ears of 37 controls were extracted using a clinical procedure commonly associated with local pain. One month later, earwax from the left ear side was extracted using the same procedure, and earwax from the right ear side was more comfortably obtained, using a novel earwax self-sampling device. Participants also provided one centimetre of hair that represented the retrospective month of cortisol output, and one serum sample that reflected the effect of systemic stressors on cortisol levels. Earwax (ECC), Hair (HCC) and Serum (SCC) Cortisol Concentration were correlated and compared. Confounders' effect on cortisol levels were studied. Results: The highest levels of cortisol concentration were found in serum, and the lowest in hair (p < 0.01). Left-ECC was larger than Right-ECC (p = 0.03). Right-ECC was the only sample unaffected by confounders (all p > 0.05). A Pearson correlation showed that Right-ECC and HCC samples were moderately correlated between them (r = 0.39; p = 0.03). Conclusions: The self-sampling device did not increase cortisol locally. It provided the cortisol level that was least likely to be affected by confounding factors over the previous month. ECC using the novel device might constitute another accurate, but more suitable and affordable specimen for measuring chronic cortisol concentration.
【 授权许可】
Unknown