New drugs in psychiatry: focus on new pharmacological targets [version 1; referees: 3 approved]

F1000Research

Filippo Drago¹  Gian Marco Leggio¹  Salvatore Salomone¹  Filippo Caraci² 

[1] Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy;IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina (EN), Italy;

关键词: Behavioral Neuroscience;    Cognitive Neurology & Dementia;    Cognitive Neuroscience;    Drug Discovery & Design;    Immunopharmacology & Hematologic Pharmacology;    Mood Disorders;    Neurobiology of Disease & Regeneration;    Neuronal Signaling Mechanisms;    Neuropharmacology & Psychopharmacology;    Schizophrenia & Other Psychoses;    Substance Abuse;   

DOI  :  10.12688/f1000research.10233.1

来源: DOAJ

【 摘 要 】

The approval of psychotropic drugs with novel mechanisms of action has been rare in recent years. To address this issue, further analysis of the pathophysiology of neuropsychiatric disorders is essential for identifying new pharmacological targets for psychotropic medications. In this report, we detail drug candidates being examined as treatments for psychiatric disorders. Particular emphasis is placed on agents with novel mechanisms of action that are being tested as therapies for depression, schizophrenia, or Alzheimer’s disease. All of the compounds considered were recently approved for human use or are in advanced clinical trials. Drugs included here are new antipsychotic medications endowed with a preferential affinity at dopamine D3 receptor (cariprazine) or at glutamatergic or cannabinoid receptors, as well as vortioxetine, a drug approved for managing the cognitive deficits associated with major depression. New mechanistic approaches for the treatment of depression include intravenous ketamine or esketamine or intranasal esketamine. As for Alzheimer’s disease, the possible value of passive immunotherapy with agents such as aducanumab is considered to be a potential disease-modifying approach that could slow or halt the progressive decline associated with this devastating disorder.

【 授权许可】

Unknown